Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor

• Автори: Yaling Zhang (Автор), Li Chen (Автор), Xiabing Li (Автор), Li Gao (Автор), Yunxia Hao (Автор), Baolin Li (Автор), Yaping Yan (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Herein, four novel 4-arylaminoquinazoline derivatives with N,N-diethyl(aminoethyl)amino moiety were designed, synthesised and evaluated on biological activities in vitro. All synthesised compounds have inhibitory effects against tumour cells (SW480, A549, A431 and NCI-H1975). In particular, 4-(3-chl...