CYP-Dependent Metabolism of PF9601N, A New Monoamine Oxidase-B Inhibitor, by C57BL / 6 Mouse and Human Liver Microsomes

• Main Authors: Stefania Dragoni (Author), Giada Materozzi (Author), Federica Pessina (Author), Maria Frosini (Author), José Luis Marco (Author), Mercedes Unzeta (Author), Giampietro Sgaragli (Author), Massimo Valoti (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2007-10-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine. Subsequently, this has promoted the design of a novel, more potent, MAO-B i...