Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine

Metformin is an important antidiabetic drug and often used as a probe for drug-drug interactions (DDIs) mediated by renal transporters. Despite evidence supporting the inhibition of multidrug and toxin extrusion proteins as the likely DDI mechanism, the previously reported physiologically‐based phar...

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Main Authors: Kotaro Nishiyama (Author), Kota Toshimoto (Author), Wooin Lee (Author), Naoki Ishiguro (Author), Bojan Bister (Author), Yuichi Sugiyama (Author)
Format: Book
Published: Wiley, 2019-06-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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