TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion

TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion

Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells remains unknown. We previously determined that in β-c...

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Main Authors: Nicholas C. Vierra (Author), Matthew T. Dickerson (Author), Kelli L. Jordan (Author), Prasanna K. Dadi (Author), Ketaki A. Kadare (Author), Molly K. Altman (Author), Sarah C. Milian (Author), David A. Jacobson (Author)
Format: Book
Published: Elsevier, 2018-03-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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