Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses

• Main Authors: Michael Donkor (Author), Jamie Choe (Author), Danielle Marie Reid (Author), Byron Quinn (Author), Mark Pulse (Author), Amalendu Ranjan (Author), Pankaj Chaudhary (Author), Harlan P. Jones (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung metastasis is a leading cause of cancer-related deaths. Here, we show that intranasal delivery of our engineered CpG-coated tumor antigen (Tag)-encapsulated nanoparticles (NPs)-nasal nano-vaccine-significantly reduced lung colonization by intravenous challenge of an extra-pulmonary tumor. Prote...