Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, HEC30654, in Healthy Chinese Subjects

• Main Authors: Xiaojiao Li (Author), Lei Gao (Author), Jingrui Liu (Author), Hong Zhang (Author), Hong Chen (Author), Lizi Yang (Author), Min Wu (Author), Cuiyun Li (Author), Xiaoxue Zhu (Author), Yanhua Ding (Author), Li Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Objective: HEC30654 is a selective 5-HT6 receptor antagonist that was safe and well-tolerated in preclinical models of Alzheimer's disease. The objective of this double-blind, randomized, placebo-controlled clinical trial was to evaluate the safety, tolerability, and pharmacokine...