FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease

• Main Authors: Cheng Zhang (Author), Feng Chen (Author), Li Feng (Author), Qun Shan (Author), Gui-Hong Zheng (Author), Yong-Jian Wang (Author), Jun Lu (Author), Shao-Hua Fan (Author), Chun-Hui Sun (Author), Dong-Mei Wu (Author), Meng-Qiu Li (Author), Bin Hu (Author), Qing-Qing Wang (Author), Zi-Feng Zhang (Author), Yuan-Lin Zheng (Author)
• Format: Book
• Published: BMC, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Innate immune dysfunction contributes to the development and progression of nonalcoholic fatty liver disease (NAFLD), however, its pathogenesis is still incompletely understood. Identifying the key innate immune component responsible for the pathogenesis of NAFLD and clarifying t...