Myosin Light Chain Kinase Knockout Improves Gut Barrier Function and Confers a Survival Advantage in Polymicrobial Sepsis

• Main Authors: C. Adam Lorentz (Author), Zhe Liang (Author), Mei Meng (Author), Ching-Wen Chen (Author), Benyam P. Yoseph (Author), Elise R. Breed (Author), Rohit Mittal (Author), Nathan J. Klingensmith (Author), Alton B. Farris (Author), Eileen M. Burd (Author), Michael Koval (Author), Mandy L. Ford (Author), Craig M. Coopersmith (Author)
• Format: Book
• Published: BMC, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the perijunctional actin-myosin ring. Myosin light chain kinase (MLCK) phosphorylates the myosin regulatory light chain, resulting in increased permeabili...