Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice

• Main Authors: Irene Hernández-Lozano (Author), Severin Mairinger (Author), Alexander Traxl (Author), Michael Sauberer (Author), Thomas Filip (Author), Johann Stanek (Author), Claudia Kuntner (Author), Thomas Wanek (Author), Oliver Langer (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are co-localized at the blood-brain barrier, where they display functional redundancy to restrict the brain distribution of dual P-gp/BCRP substrate drugs. We used positron emission tomography (PET) with the metabolically stable P-gp/...