Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase

• Main Authors: Maria Luisa Di Paolo (Author), Manuela Cervelli (Author), Paolo Mariottini (Author), Alessia Leonetti (Author), Fabio Polticelli (Author), Michela Rosini (Author), Andrea Milelli (Author), Filippo Basagni (Author), Rina Venerando (Author), Enzo Agostinelli (Author), Anna Minarini (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1-9) or methoctramine (10-14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and acetylpolyamine oxidase (PAOX). Compound 2 turned o...