The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding

• Main Authors: Renee A. Rotolo (Author), Vladimir Dragacevic (Author), Predrag Kalaba (Author), Ernst Urban (Author), Martin Zehl (Author), Alexander Roller (Author), Judith Wackerlig (Author), Thierry Langer (Author), Marco Pistis (Author), Maria Antonietta De Luca (Author), Francesca Caria (Author), Rebecca Schwartz (Author), Rose E. Presby (Author), Jen-Hau Yang (Author), Shanna Samels (Author), Merce Correa (Author), Gert Lubec (Author), John D. Salamone (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Animal studies of effort-based choice behavior are being used to model effort-related motivational dysfunctions in humans. With these procedures, animals are offered a choice between high-effort instrumental actions leading to highly valued reinforcers vs. low effort/low reward options. Several prev...