Exploring the relationship of hyaluronic acid molecular weight and active targeting efficiency for designing hyaluronic acid-modified nanoparticles
Although it is reported that the targeting ability of hyaluronic acid (HA)-based nanoparticles (NPs) is molecular weight (MW) dependent, the influence of HA MW on targeting efficiency of HA-functionalized NPs and the underlying mechanism remain elusive. In this study, we constituted three HA-functio...
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Elsevier,
2019-09-01T00:00:00Z.
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| 001 | doaj_1dc03cddb07b4dd284c5cfc47a7fc6a1 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Lu Zhong |e author |
| 700 | 1 | 0 | |a Yanying Liu |e author |
| 700 | 1 | 0 | |a Lu Xu |e author |
| 700 | 1 | 0 | |a Qingsong Li |e author |
| 700 | 1 | 0 | |a Dongyang Zhao |e author |
| 700 | 1 | 0 | |a Zhenbao Li |e author |
| 700 | 1 | 0 | |a Huicong Zhang |e author |
| 700 | 1 | 0 | |a Haotian Zhang |e author |
| 700 | 1 | 0 | |a Qiming Kan |e author |
| 700 | 1 | 0 | |a Jin Sun |e author |
| 700 | 1 | 0 | |a Zhonggui He |e author |
| 245 | 0 | 0 | |a Exploring the relationship of hyaluronic acid molecular weight and active targeting efficiency for designing hyaluronic acid-modified nanoparticles |
| 260 | |b Elsevier, |c 2019-09-01T00:00:00Z. | ||
| 500 | |a 1818-0876 | ||
| 500 | |a 10.1016/j.ajps.2018.11.002 | ||
| 520 | |a Although it is reported that the targeting ability of hyaluronic acid (HA)-based nanoparticles (NPs) is molecular weight (MW) dependent, the influence of HA MW on targeting efficiency of HA-functionalized NPs and the underlying mechanism remain elusive. In this study, we constituted three HA-functionalized Dox-loaded NPs (Dox/HCVs) different HA MWs (7, 63, and 102 kDa) and attempted to illustrate the effects of HA MW on the targeting efficiency. The three Dox/HCVs had similar physiochemical and pharmaceutical characteristics, but showed different affinity to CD44 receptor. Furthermore, Dox/HCV-63 exerted the best targeting effect and the highest cytotoxicity compared with Dox/HCV-7 and Dox/HCV-102. It was interesting to found that both the HA-CD44 binding affinity and induced CD44 clustering by HA-based NPs were HA MW-dependent, the two of which determine the apparent targeting efficacy of Dox/HCV NPs in the conflicting directions. Those results laid a good foundation for rationally designing HA-based NPs in cancer therapy. Keywords: Hyaluronic acid, Molecular weight, Active targeting efficiency, CD44 receptor, Potential mechanism | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Asian Journal of Pharmaceutical Sciences, Vol 14, Iss 5, Pp 521-530 (2019) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1818087618307840 | |
| 787 | 0 | |n https://doaj.org/toc/1818-0876 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1dc03cddb07b4dd284c5cfc47a7fc6a1 |z Connect to this object online. |