Prefrontal cortex infusion of beta‐hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant‐like effects in a rodent model of depression

• Main Authors: Naofumi Kajitani (Author), Masaaki Iwata (Author), Akihiko Miura (Author), Kyohei Tsunetomi (Author), Takehiko Yamanashi (Author), Ryoichi Matsuo (Author), Tsuyoshi Nishiguchi (Author), Saki Fukuda (Author), Mayu Nagata (Author), Midori Shibushita (Author), Takahira Yamauchi (Author), Shenghong Pu (Author), Yukihiko Shirayama (Author), Ken Watanabe (Author), Koichi Kaneko (Author)
• Format: Book
• Published: Wiley, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aims Neuroinflammation is deeply related to the pathophysiology of depression. Beta‐hydroxybutyrate (BHB), which is an endogenous ketone body, exerts anti‐inflammatory effects, and peripheral administration of BHB induces antidepressant effects in an animal model of depression; however, it...