The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling

• Main Authors: Ruohan Zhang (Author), Serra Ozgen (Author), Hongke Luo (Author), Judith Krigman (Author), Yutong Zhao (Author), Gang Xin (Author), Nuo Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitophagy is an intracellular mechanism to maintain mitochondrial health by removing dysfunctional mitochondria. The E3 ligase Parkin ubiquitinates the membrane proteins on targeted mitochondria to initiate mitophagy, whereas USP30 antagonizes Parkin-dependent mitophagy by removing ubiquitin from Pa...