Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising "MINT" sequencing strategy and therapeutic "DNA-TG" monitoring

• Main Authors: Hong-Li Guo (Author), Yue-Tao Zhao (Author), Wei-Jun Wang (Author), Na Dong (Author), Ya-Hui Hu (Author), Yuan-Yuan Zhang (Author), Feng Chen (Author), Li Zhou (Author), Tao Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases. However, the common adverse effects caused by myelosuppression and hepatotoxicity l...