Characterization and Mathematical Modeling of Alginate/Chitosan-Based Nanoparticles Releasing the Chemokine CXCL12 to Attract Glioblastoma Cells

• Main Authors: Suzanne Gascon (Author), Angéla Giraldo Solano (Author), Wiam El Kheir (Author), Hélène Therriault (Author), Pierre Berthelin (Author), Bettina Cattier (Author), Bernard Marcos (Author), Nick Virgilio (Author), Benoit Paquette (Author), Nathalie Faucheux (Author), Marc-Antoine Lauzon (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chitosan (Chit) currently used to prepare nanoparticles (NPs) for brain application can be complexed with negatively charged polymers such as alginate (Alg) to better entrap positively charged molecules such as CXCL12. A sustained CXCL12 gradient created by a delivery system can be used, as a therap...