Cellular uptake of modified mRNA occurs via caveolae-mediated endocytosis, yielding high protein expression in slow-dividing cells

• Main Authors: Claudia Del Toro Runzer (Author), Shivesh Anand (Author), Carlos Mota (Author), Lorenzo Moroni (Author), Christian Plank (Author), Martijn van Griensven (Author), Elizabeth R. Balmayor (Author)
• 格式: 图书
• 出版: Elsevier, 2023-06-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Nucleic acids have clear clinical potential for gene therapy. Plasmid DNA (pDNA) was the first nucleic acid to be pursued as a therapeutic molecule. Recently, mRNA came into play as it offers improved safety and affordability. In this study, we investigated the uptake mechanisms and efficiencies of...