Molecular and Structural Aspects of Clinically Relevant Mutations of SARS-CoV-2 RNA-Dependent RNA Polymerase in Remdesivir-Treated Patients

• Main Authors: Carmen Gratteri (Author), Francesca Alessandra Ambrosio (Author), Antonio Lupia (Author), Federica Moraca (Author), Bruno Catalanotti (Author), Giosuè Costa (Author), Maria Bellocchi (Author), Luca Carioti (Author), Romina Salpini (Author), Francesca Ceccherini-Silberstein (Author), Simone La Frazia (Author), Vincenzo Malagnino (Author), Loredana Sarmati (Author), Valentina Svicher (Author), Sharon Bryant (Author), Anna Artese (Author), Stefano Alcaro (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is a promising therapeutic target to fight COVID-19, and many RdRp inhibitors nucleotide/nucleoside analogs, such as remdesivir, have been identified or are in clinical studies. However, the appearance of resistant mutations could reduce...