The Discovery of Dabigatran Etexilate

• Main Authors: Joanne evan Ryn (Author), Ashley M Goss (Author), Norbert eHauel (Author), Wolfgang eWienen (Author), Henning ePriepke (Author), Herbert eNar (Author), Andreas eClemens (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thromboembolic disease is a major cause of mortality and morbidity in the developed world and is caused by an excessive stimulation of coagulation. Thrombin is a key serine protease in the coagulation cascade and numerous efforts have been made to develop safe and effective orally active direct thro...