Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy

• Main Authors: Mingyang Zhang (Author), Yifan Miao (Author), Can Zhao (Author), Tong Liu (Author), Xiyan Wang (Author), Zixuan Wang (Author), Wenxin Zhong (Author), Zhonggui He (Author), Chutong Tian (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of reducing substances (e.g., ascorbic acid, glutathione, uric acid and tea polyphenol...