Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy

• 主要な著者: Mingyang Zhang (著者), Yifan Miao (著者), Can Zhao (著者), Tong Liu (著者), Xiyan Wang (著者), Zixuan Wang (著者), Wenxin Zhong (著者), Zhonggui He (著者), Chutong Tian (著者), Jin Sun (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2024-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of reducing substances (e.g., ascorbic acid, glutathione, uric acid and tea polyphenol...