A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus

• Main Authors: Lai Wang (Author), Haoyuan Yin (Author), Jiao Jiang (Author), Qilin Li (Author), Changxing Gao (Author), Wenrui Li (Author), Bo Zhang (Author), Yue Xin (Author), Hongyang Li (Author), Ming Zhao (Author), Qianjin Lu (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tripterygium wilfordii Hook F (TWHF) is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus (SLE), with triptolide (TP) as its main active ingredient. However, its side effects also induced by TP, especially hepatotoxicity and reproductive toxicity, largely li...