Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis

• Main Authors: Qiaoli Li (Author), Michael Frank (Author), Masashi Akiyama (Author), Hiroshi Shimizu (Author), Shiu-Ying Ho (Author), Christine Thisse (Author), Bernard Thisse (Author), Eli Sprecher (Author), Jouni Uitto (Author)
• Format: Book
• Published: The Company of Biologists, 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Zebrafish (Danio rerio) can serve as a model system to study heritable skin diseases. The skin is rapidly developed during the first 5-6 days of embryonic growth, accompanied by expression of skin-specific genes. Transmission electron microscopy (TEM) of wild-type zebrafish at day 5 reveals...