Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan

• Main Authors: Kaori Mukai (Author), Robert Cost (Author), Xin Sheen Zhang (Author), Emily Condiff (Author), Joanne Cotton (Author), Xiaohua Liu (Author), Ekaterina Boudanova (Author), Björn Niebel (Author), Peter Piepenhagen (Author), Xinming Cai (Author), Anna Park (Author), Qun Zhou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology. Among them, Lysosome-Targeting Chimeras (LYTACs) acting through mannose 6-phosphate receptor...