Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors

• Hoofdauteurs: Samar El-Kalyoubi (Auteur), Samiha A. El-Sebaey (Auteur), A. M. Rashad (Auteur), Hanan A. AL-Ghulikah (Auteur), Mostafa M. Ghorab (Auteur), Sherin M. Elfeky (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Novel series of aminopyrimidines bearing a biologically active cyclohexenone 3a-f and oxo-selaneylidene moiety 4, besides selenadiazolopyrimidines (5a-e and 7), were synthesised using 5,6-diaminouracils as starting materials. Compound 3a exhibited strong anti-proliferative activity against three cel...