Prolonged exposure of colon cancer cells to 5-fluorouracil nanoparticles improves its anticancer activity

• Main Authors: Essam Tawfik (Author), Maqusood Ahamed (Author), Abdulaziz Almalik (Author), Mohammad Alfaqeeh (Author), Aws Alshamsan (Author)
• Format: Book
• Published: Elsevier, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we aimed to improve the anticancer effect of 5-FU on human colon cancer cell lines by incorporating in poly(d,l lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). The 5-FU-PLGA NPs were prepared by nanoprecipitation technique. Prepared NPs were moderately dispersed with an average d...