Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers

Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers

Activated hepatic stellate cells (aHSCs) are the main orchestrators of the fibrotic cascade in inflamed livers, with transforming growth factor-beta (TGF-β) being the most potent pro-fibrotic cytokine. Hence, aHSCs serve as interesting therapeutic targets. However, drug delivery to aHSCs is hindered...

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Main Authors: Menna Azzam (Author), Sara El Safy (Author), Sarah A. Abdelgelil (Author), Ralf Weiskirchen (Author), Anastasia Asimakopoulou (Author), Federica de Lorenzi (Author), Twan Lammers (Author), Samar Mansour (Author), Salma Tammam (Author)
Format: Book
Published: MDPI AG, 2020-06-01T00:00:00Z.
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3rd Floor Main Library

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