Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers

• Main Authors: Menna Azzam (Author), Sara El Safy (Author), Sarah A. Abdelgelil (Author), Ralf Weiskirchen (Author), Anastasia Asimakopoulou (Author), Federica de Lorenzi (Author), Twan Lammers (Author), Samar Mansour (Author), Salma Tammam (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activated hepatic stellate cells (aHSCs) are the main orchestrators of the fibrotic cascade in inflamed livers, with transforming growth factor-beta (TGF-β) being the most potent pro-fibrotic cytokine. Hence, aHSCs serve as interesting therapeutic targets. However, drug delivery to aHSCs is hindered...