Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING

• Main Authors: Ting-Ting Yu (Author), Ning Han (Author), Liu-Gen Li (Author), Xing-Chun Peng (Author), Qi-Rui Li (Author), Hua-Zhen Xu (Author), Xi-Yong Wang (Author), Zi-Yi Yang (Author), Xiao Chen (Author), Mei-Fang Wang (Author), Tong-Fei Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tumor-associated macrophage (TAM) serves as an immunosuppressive agent in the malignant tumor microenvironment, facilitating the development and metastasis of lung cancer. The photodynamic effect destabilizes cellular homeostasis owing to the generation of reactive oxygen species (ROS), resultin...