Floating microspheres of valacyclovir HCl: Formulation, optimization, characterization, in vitro and in vivo floatability studies

• Hauptverfasser: Nilamgiri Goswami (Verfasst von), Garima Joshi (Verfasst von), Krutika Sawant (Verfasst von)
• Format: Buch
• Veröffentlicht: Wolters Kluwer Medknow Publications, 2012-01-01T00:00:00Z.
• Schlagworte: article
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Floating microspheres are multiple unit Gastroretentive drug delivery systems. Valacyclovir hydrochloride (VCH) is L-valyl ester prodrug of acyclovir. VCH degrades in intestinal fluid. The objective was to develop floating microspheres of VCH to localise the drug at upper part of GIT, for improved a...