Structure-activity relationship investigation of benzamide and picolinamide derivatives containing dimethylamine side chain as acetylcholinesterase inhibitors

• Main Authors: Xiao-hui Gao (Author), Lin-bo Liu (Author), Hao-ran Liu (Author), Jing-jing Tang (Author), Lu Kang (Author), Hongnian Wu (Author), Peiwu Cui (Author), Jianye Yan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of benzamide and picolinamide derivatives containing dimethylamine side chain (4a-4c and 7a-7i) were synthesised and evaluated for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity in vitro. Structure-activity relationship investigation revealed that the subst...