Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death

• Main Authors: Andy Shao (Author), Antonio Jacobo Lopez (Author), JiaJia Chen (Author), Addy Tham (Author), Seanne Javier (Author), Alejandra Quiroz (Author), Sonia Frick (Author), Edward M. Levine (Author), K. C. Kent Lloyd (Author), Brian C. Leonard (Author), Christopher J. Murphy (Author), Thomas M. Glaser (Author), Ala Moshiri (Author)
• Format: Book
• Published: The Company of Biologists, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1−/− mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activating protein shown to modulate actin cytoskeletal dynamic...