New Insights into the Binding Features of F508del CFTR Potentiators: A Molecular Docking, Pharmacophore Mapping and QSAR Analysis Approach

• Main Authors: Giada Righetti (Author), Monica Casale (Author), Michele Tonelli (Author), Nara Liessi (Author), Paola Fossa (Author), Nicoletta Pedemonte (Author), Enrico Millo (Author), Elena Cichero (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cystic fibrosis (CF) is the autosomal recessive disorder most recurrent in Caucasian populations. To combat this disease, many life-prolonging therapies are required and deeply investigated, including the development of the so-called cystic fibrosis transmembrane conductance regulator (CFTR) modulat...