The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes

• Main Authors: Julia Eisele (Author), Simone Schreiner (Author), Joscha Borho (Author), Stephan Fischer (Author), Sebastian Heber (Author), Sascha Endres (Author), Maximilian Fellermann (Author), Lisa Wohlgemuth (Author), Markus Huber-Lang (Author), Giorgio Fois (Author), Michael Fauler (Author), Manfred Frick (Author), Holger Barth (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects on mammalian cells, proteolytically activated C2II (C2IIa) forms barrel-shaped heptamers that bind to carbohydrate r...