The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes

• Үндсэн зохиолчид: Julia Eisele (Зохиогч), Simone Schreiner (Зохиогч), Joscha Borho (Зохиогч), Stephan Fischer (Зохиогч), Sebastian Heber (Зохиогч), Sascha Endres (Зохиогч), Maximilian Fellermann (Зохиогч), Lisa Wohlgemuth (Зохиогч), Markus Huber-Lang (Зохиогч), Giorgio Fois (Зохиогч), Michael Fauler (Зохиогч), Manfred Frick (Зохиогч), Holger Barth (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects on mammalian cells, proteolytically activated C2II (C2IIa) forms barrel-shaped heptamers that bind to carbohydrate r...