The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes

• Váldodahkkit: Julia Eisele (Dahkki), Simone Schreiner (Dahkki), Joscha Borho (Dahkki), Stephan Fischer (Dahkki), Sebastian Heber (Dahkki), Sascha Endres (Dahkki), Maximilian Fellermann (Dahkki), Lisa Wohlgemuth (Dahkki), Markus Huber-Lang (Dahkki), Giorgio Fois (Dahkki), Michael Fauler (Dahkki), Manfred Frick (Dahkki), Holger Barth (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects on mammalian cells, proteolytically activated C2II (C2IIa) forms barrel-shaped heptamers that bind to carbohydrate r...