Immunoglobulin Heavy Chain High-Throughput Sequencing in Pediatric B-Precursor Acute Lymphoblastic Leukemia: Is the Clonality of the Disease at Diagnosis Related to Its Prognosis?

• Main Authors: Gabriel Levy (Author), Michal Kicinski (Author), Jona Van der Straeten (Author), Anne Uyttebroeck (Author), Alina Ferster (Author), Barbara De Moerloose (Author), Marie-Francoise Dresse (Author), Christophe Chantrain (Author), Bénédicte Brichard (Author), Marleen Bakkus (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-throughput sequencing (HTS) of the immunoglobulin heavy chain (IgH) locus is a recent very efficient technique to monitor minimal residual disease of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It also reveals the sequences of clonal rearrangements, therefore, the multiclonal struc...