A large unilateral basal cell carcinoma treated with Hedgehog inhibitor sonidegib: a case report

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. BCCs are categorized into "easy-to-treat" and "difficult-to-treat" groups, with the latter including all BCCs that are challenging to manage due to technical, patient-related, or tumor-related factors, such a...

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Main Authors: Maria Alessandra Mattioli (Author), Valentina Benzecry (Author), Giulia Murgia (Author), Nerina Denaro (Author), Angelo Valerio Marzano (Author), Emanuela Passoni (Author), Gianluca Nazzaro (Author)
Format: Book
Published: PAGEPress Publications, 2024-11-01T00:00:00Z.
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Summary:Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. BCCs are categorized into "easy-to-treat" and "difficult-to-treat" groups, with the latter including all BCCs that are challenging to manage due to technical, patient-related, or tumor-related factors, such as locally advanced BCCs. In this report, we describe an 84-year-old patient with an extensive, unilateral BCC. Following a decision by the multidisciplinary skin cancer board, the patient was successfully treated with a daily dose of 200 mg of sonidegib, an inhibitor of the Hedgehog pathway, for eight months, acquiring complete clinical and histopathological remission. No significant side effects were reported. The follow-up period of 24 months has shown no negative results.
Item Description:10.4081/dr.2024.10152
2036-7392
2036-7406