Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans

• Main Authors: Hans Peter Grimm (Author), Vanessa Schumacher (Author), Martin Schäfer (Author), Sabine Imhof-Jung (Author), Per-Ola Freskgård (Author), Kevin Brady (Author), Carsten Hofmann (Author), Petra Rüger (Author), Tilman Schlothauer (Author), Ulrich Göpfert (Author), Maximilian Hartl (Author), Sylvia Rottach (Author), Adrian Zwick (Author), Shanon Seger (Author), Rachel Neff (Author), Jens Niewoehner (Author), Niels Janssen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThere are few treatments that slow neurodegeneration in Alzheimer's disease (AD), and while therapeutic antibodies are being investigated in clinical trials for AD treatment, their access to the central nervous system is restricted by the blood-brain barrier. This study investigates a b...