B7-H3 expression is associated with high PD-L1 expression in clear cell renal cell carcinoma and predicts poor prognosis

• Main Authors: Jung Hee Lee (Author), Yong Jun Kim (Author), Hyun Woo Ryu (Author), Seung Won Shin (Author), Eun Ji Kim (Author), So Hyun Shin (Author), Joon Young Park (Author), So Young Kim (Author), Chung Su Hwang (Author), Joo-Young Na (Author), Dong Hoon Shin (Author), Jee Yeon Kim (Author), Hyun Jung Lee (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Clear cell Renal cell carcinoma (ccRCC) is an immunogenic tumor. B7 family members, such as CTLA-4, PD-1, and PD-L1, are the main components of immune checkpoints that regulate various immune responses. Specifically, B7-H3 regulates T cell-mediated immune responses against cancer...