Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth

• Main Authors: Lulu Guan (Author), Yalan Yang (Author), Yao Lu (Author), Yu Chen (Author), Xi Luo (Author), Dao Xin (Author), Xiangrui Meng (Author), Zhengzheng Shan (Author), Guozhong Jiang (Author), Feng Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

p53 mutations are prevalent in human cancers; approximately half of patients with esophageal cancer present these mutations. Mutant p53 (mutp53) exerts oncogenic functions that promote malignant tumor progression, invasion, metastasis, and drug resistance, resulting in poor prognosis. Some small mol...