In silico analysis of six known Leishmania major antigens and in vitro evaluation of specific epitopes eliciting HLA-A2 restricted CD8 T cell response.

• Main Authors: Negar Seyed (Author), Farnaz Zahedifard (Author), Shima Safaiyan (Author), Elham Gholami (Author), Fatemeh Doustdari (Author), Kayhan Azadmanesh (Author), Maryam Mirzaei (Author), Nasir Saeedi Eslami (Author), Akbar Khadem Sadegh (Author), Ali Eslami Far (Author), Iraj Sharifi (Author), Sima Rafati (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: As a potent CD8(+) T cell activator, peptide vaccine has found its way in vaccine development against intracellular infections and cancer, but not against leishmaniasis. The first step toward a peptide vaccine is epitope mapping of different proteins according to the most frequent HLA ty...