Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

• Main Authors: Scott A. Nelson (Author), Zhouyu Li (Author), Ian P. Newton (Author), David Fraser (Author), Rachel E. Milne (Author), David M. A. Martin (Author), David Schiffmann (Author), Xuesong Yang (Author), Dirk Dormann (Author), Cornelis J. Weijer (Author), Paul L. Appleton (Author), Inke S. Näthke (Author)
• Format: Book
• Published: The Company of Biologists, 2012-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Nonsense mutations that result in the expression of truncated, N-terminal, fragments of the adenomatous polyposis coli (APC) tumour suppressor protein are found in most sporadic and some hereditary colorectal cancers. These mutations can cause tumorigenesis by eliminating β-catenin-binding s...