A new murine model of stress-induced complex atherosclerotic lesions

• Main Authors: Amir H. Najafi (Author), Nima Aghili (Author), Justin U. Tilan (Author), James A. Andrews (Author), XinZhi Peng (Author), Roberta M. Lassance-Soares (Author), Subeena Sood (Author), Lee O. Alderman (Author), Ken Abe (Author), Lijun Li (Author), Frank D. Kolodgie (Author), Renu Virmani (Author), Zofia Zukowska (Author), Stephen E. Epstein (Author), Mary Susan Burnett (Author)
• Format: Book
• Published: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The primary purpose of this investigation was to determine whether ApoE−/− mice, when subjected to chronic stress, exhibit lesions characteristic of human vulnerable plaque and, if so, to determine the time course of such changes. We found that the lesions were remarkably similar to human vu...