Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

• Main Authors: Asmaa A. Mandour (Author), Ibrahim F. Nassar (Author), Mohammed T. Abdel Aal (Author), Mahmoud A. E. Shahin (Author), Wael A. El-Sayed (Author), Maghawry Hegazy (Author), Amr Mohamed Yehia (Author), Ahmed Ismail (Author), Mohamed Hagras (Author), Eslam B. Elkaeed (Author), Hanan M. Refaat (Author), Nasser S. M. Ismail (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established for their antitumor activity via CDK2 inhibition. In this research, new series of pyrazolopyrimidine derivativ...