Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes

• Main Authors: Muluneh M. Fashe (Author), John K. Fallon (Author), Taryn A. Miner (Author), Jacqueline B. Tiley (Author), Philip C. Smith (Author), Craig R. Lee (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pregnancy alters the disposition and exposure to multiple drugs indicated for pregnancy-related complications. Previous in vitro studies have shown that pregnancy-related hormones (PRHs) alter the expression and function of certain cytochrome P450s (CYPs) in human hepatocytes. However, the impact of...