Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin

• Main Authors: Yixing Lu (Author), Liuye Yang (Author), Wanying Zhang (Author), Shiting Xie (Author), Feifei Zhao (Author), Xianfeng Peng (Author), Zonghua Qin (Author), Dongping Zeng (Author), Zhenling Zeng (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isopropoxy benzene guanidine (IBG) is a novel substituted benzene guanidine analogue with antibacterial activity against multidrug-resistant bacteria. However, the bioavailability of IBG is not optimal due to its finite aqueous solubility, thus hampering its potential therapeutic exploitation. In th...