Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis

• Main Authors: M. Isabel García-Laorden (Author), Ingrid Stroo (Author), Sanne Terpstra (Author), Sandrine Florquin (Author), Jan Paul Medema (Author), Cornelis van´t Veer (Author), Alex F. de Vos (Author), Tom van der Poll (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Escherichia (E.) coli is the most common causative pathogen in peritonitis, the second most common cause of sepsis. Granzymes (gzms) are serine proteases traditionally implicated in cytotoxicity and, more recently, in the inflammatory response. We here sought to investigate the role of gzms in the h...