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Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine.

Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial de...

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Main Authors: Thomas P C Dorlo (Author), Pieter P A M van Thiel (Author), Gerard J Schoone (Author), Ymkje Stienstra (Author), Michèle van Vugt (Author), Jos H Beijnen (Author), Peter J de Vries (Author)
Format: Book
Published: Public Library of Science (PLoS), 2011-12-01T00:00:00Z.
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Summary:Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of ∼1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.
Item Description:1935-2735
10.1371/journal.pntd.0001436

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