Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy

• Main Authors: Bin Yang (Author), Lin Wei (Author), Yuequan Wang (Author), Na Li (Author), Bin Ji (Author), Kaiyuan Wang (Author), Xuanbo Zhang (Author), Shenwu Zhang (Author), Shuang Zhou (Author), Xiaohui Yao (Author), Hang Song (Author), Yusheng Wu (Author), Haotian Zhang (Author), Qiming Kan (Author), Tao Jin (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors. Tumor cells generally display the higher oxidative level than normal cells, and also displayed the heterogeneity in terms of redox homeostasis level. We previously found that...