Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology

• Main Authors: Srikanth Mairpady Shambat (Author), Puran Chen (Author), Anh Thu Nguyen Hoang (Author), Helena Bergsten (Author), Francois Vandenesch (Author), Nikolai Siemens (Author), Gerard Lina (Author), Ian R. Monk (Author), Timothy J. Foster (Author), Gayathri Arakere (Author), Mattias Svensson (Author), Anna Norrby-Teglund (Author)
• Format: Book
• Published: The Company of Biologists, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Staphylococcus aureus necrotizing pneumonia is recognized as a toxin-mediated disease, yet the tissue-destructive events remain elusive, partly as a result of lack of mechanistic studies in human lung tissue. In this study, a three-dimensional (3D) tissue model composed of human lung epithelial cell...