Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes

• Main Authors: Federica Matteucci (Author), Marta Ferrati (Author), Eleonora Spinozzi (Author), Alessia Piergentili (Author), Fabio Del Bello (Author), Gianfabio Giorgioni (Author), Leonardo Sorci (Author), Riccardo Petrelli (Author), Loredana Cappellacci (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nicotinamide adenine dinucleotide (NAD) cofactor metabolism plays a significant role in cancer development. Tumor cells have an increased demand for NAD and ATP to support rapid growth and proliferation. Limiting the amount of available NAD by targeting critical NAD biosynthesis enzymes has emerged...