The Organ Handling of Soluble Klotho in Humans

• Main Authors: Daniela Picciotto (Author), Abitha Murugavel (Author), Francesca Ansaldo (Author), Gian Marco Rosa (Author), Antonella Sofia (Author), Samantha Milanesi (Author), Francesca Viazzi (Author), Michela Saio (Author), Manrico Balbi (Author), Giacomo Garibotto (Author), Daniela Verzola (Author)
• Format: Book
• Published: Karger Publishers, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Chronic kidney disease (CKD) reduces both Klotho expression and its shedding into circulation, an effect that accelerates progression and cardiovascular complications. However, the mechanisms that regulate Klotho release by the human kidney are still unknown. Methods: We measured plasma...